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Spit tobacco users have 50 times more likely chance of developing mouth cancers than non-users

The following information was extracted from each study: the first authors surname, publication year, location (country or region) of the conducted study, follow-up time, the total number of participants and cancer cases identified among them, age of the participants, smoking categorization used, relative risk (RR) or hazard ratio (HR) estimate for each smoking category, and the corresponding 95% confidence interval, and finally the confounder variable that was adjusted for in the analysis

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adults, particularly among populations with the highest rates of use